Rapid one-pot radiosynthesis of [carbonyl-11C]formamides from primary amines and [11C]CO2
نویسندگان
چکیده
منابع مشابه
Heterogeneous Ru-Based Catalysts for One-Pot Synthesis of Primary Amines from Aldehydes and Ammonia
The direct reductive amination of carbonyl compounds with NH3 and H2 is an alternative route to produce primary amines in practical production. The search for efficient and selective catalysts has attracted great interest. In the present work, the reductive amination of heptaldehyde with NH3 was investigated over a Ru-based catalyst. The product selectivities were found to be related with the s...
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BACKGROUND Glycine N-methyltransferase is an enzyme overexpressed in some neoplastic tissues. It catalyses the methylation of glycine using S-adenosyl methionine (SAM or AdoMet) as substrate. SAM is involved in a great variety of biochemical processes, including transmethylation reactions. Thus, [11C]SAM could be used to evaluate transmethylation activity in tumours. The only method reported fo...
متن کاملA one-pot approach to pyridyl isothiocyanates from amines.
A one-pot preparation of pyridyl isothiocyanates (ITCs) from their corresponding amines has been developed. This method involves aqueous iron(III) chloride-mediated desulfurization of a dithiocarbamate salt that is generated in situ by treatment of an amine with carbon disulfide in the present of DABCO or sodium hydride. The choice of base is of decisive importance for the formation of the dith...
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INTRODUCTION GR103545 is a potent and selective kappa-opioid receptor agonist. Previous studies in non-human primates demonstrated favorable properties of [(11)C]GR103545 as a positron emission tomography tracer for in vivo imaging of cerebral kappa-opioid receptor. Nonetheless, advancement of [(11)C]GR103545 to imaging studies in humans was hampered by difficulties of its multiple-step radiosy...
متن کاملOne-pot one-step deracemization of amines using ω-transaminases.
In this study, we developed a one-pot one-step deracemization method for the production of various enantiomerically pure amines using two opposite enantioselective ω-TAs. Using this method, various aromatic amines were successfully converted to their (R)-forms (>99%) with good conversion.
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ژورنال
عنوان ژورنال: EJNMMI Radiopharmacy and Chemistry
سال: 2020
ISSN: 2365-421X
DOI: 10.1186/s41181-020-00103-y